MTHFR Methylation & The Weight Loss Link

MTHFR weight loss

MTHFR – Methylation & The Weight Loss Link.

I see so many clients struggling with the

weight loss challenge. Often, these clients

no matter how hard they seem to try, diets

and exercise, weight loss is slow compared

to others and incredibly quick to regain,

often with many other health conditions in

the background. Commonly many end up

MTHFR positive, and when addressed,

these clients start to see significant

changes in their overall health and weight

for the first time.

What is MTHFR?

(MTHFR) Methylenetetrahydrofolate

reductase  is a gene that provides

instructions for making the enzyme

methylenetetrahydrofolate reductase

which converts 5,10

methylenetetrahydrofolate to 5-methyltetrahydrofolate.

This is required to convert homocysteine

to methionine which the body uses to

make proteins and other compounds in

the body. More simply, it converts folate in

your leafy greens to a more active form of

folate (methyl folate), to be used by the

body. This enzyme is a component of the

one-carbon metabolism pathway; or more

commonly known as the methylation

process and studies now show MTHFR

polymorphism play a significant role in the

bodies metabolic factors.

WHAT conditions are associated with methylation?

Methylation is a dynamic process that

requires balance. Many health issues are

associated with fluctuations in the

methylation process including: ADHD,

Alzheimer’s disease, anxiety,

Atherosclerosis, Bipolar disorders,

Cancers, Chemical sensitivities, Chronic

fatigue, Diabetes, Depression, Down

syndrome, Hypertension, Fertility issues,

Inflammatory Conditions  Insomnia,

Neural tube defects, Parkinson’s

disease, Schizophrenia, Weight loss,

Metabolic syndrome and many more.

If I get a positive result what does it mean?

A positive result means something

different for each individual. Not all people with

the gene  ill known in ‘gene talk’ as turned

on or expressing and present with health

issues. Genes expressing or turning on for

each individual have many factors, such

stress, environmental toxin load, diet,

lifestyle etc.

What is methylation and why is it so important?

Methylation is involved in a number of

important biochemical processes in the body

including gene expression, DNA and RNA

synthesis, immune cell differentiation,

neurotransmitter synthesis, histamine

clearance, detoxification, hormones,

mitochondrial metabolism, phospholipid

synthesis and myelination, and neural

tube development. It occurs in almost all

cells in the body. Methylation involves the

transfer of active methyl groups and when

utilised, SAMe (Sadenosylmethionine) is converted to SAH (S-adenosylhomocysteine), and then

homocysteine. The recycling of

homocysteine to methionine can occur via

two pathways – via methionine synthase

conversion that requires the transfer of a

methylgroup from 5-methylenetetrahydrofolate reductase (5-

MTHFR) by MTHFR or via betaine

homocysteine methyltransferase (BHMT).

During higher states of oxidative stress,

homocysteine may be converted to

and then to taurine, glutathione or sulfate

via the transulfuration pathway


Do you struggle with weight loss or health

conditions and feel there is something

else that may be going on? Book in for

testing and treatment today.

Jan x